Hydroxyethyl photolinker4/20/2023 They are typically built using electrostatic interactions between polymer layers, which gives high control of the final shell thickness and leads to their multi-functional and multi-compartmental features. Among the diverse nanocarriers (NCs) for cancer drug delivery studied in recent decades, layer-by-layer (LbL) polymeric nanocapsules have become the focus of interest. Nanomaterials arose from the fusion between nanotechnology and biomedicine and have various advantages compared with traditional therapies, such as targeted delivery, controlled drug release and improvement in cell barrier crossing. PNC performance has been assessed in vitro on melanoma cells as well as in vivo on xenograft tumour-induced mice. So the preparation and characterization of a photo-responsive natural nanocarrier (PNC) that is stable under physiological conditions owing to the thiol-ene cross-linkage are reported. In particular, the system is implemented with an o-nitrobenzyl group functionalized with a thiol moiety which can perform both the thiol-ene ‘click’ reaction and the cleavage meant for controlled drug release at two different wavelengths, respectively. The trilayer cross-linkage is performed via a photoinitiator-free thiol-ene ‘click’ reaction. The oil core is pre-loaded with curcumin as a model lipophilic active molecule with anti-tumoral properties. The system is made of completely biocompatible materials such as soybean oil, egg lecithin and glycol chitosan, with heparin as the polymeric shell. Here, a strategy for the preparation of a photo-responsive cross-linked trilayer deposited onto an oil-in-water nanoemulsion via a layer-by-layer technique is reported. In cancer therapy, stimulus-responsive drug delivery systems are of particular interest for reducing side effects in healthy tissues and improving drug selectivity in the tumoral ones.
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